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$\"alcohol$ <\/p>\n

This floods the system with alcohol and drastically increases the blood alcohol content in the body. As a result, the kidneys can quickly lose their function and cause lasting damage. Free radicals (also called reactive oxygen species [ROS]) are one of the by-products of alcohol metabolism and are known to cause cellular damage, unless the body can use antioxidants to clean them up. Oxidative stress occurs when the body cannot detoxify alcohol and kidneys<\/a> free radicals as fast as they are being produced, and it is pivotal in triggering alcohol-related tissue injury. Studies suggest that several mechanisms produce ROS in alcohol-damaged organs, including the liver (Cederbaum et al. 2009), heart (Tan et al. 2012; Varga et al. 2015), and kidney (Latchoumycandane et al. 2015). CYP2E1 is of particular interest when thinking about potential mechanisms for alcohol-related kidney damage.<\/p>\n<\/p>\n